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Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Optional) — PAR-25-449

National Center for Complementary and Integrative Health (NCCIH), NIH

TraditionalFederal grant

A phased award for mechanistic trials asking HOW mind and body interventions — mindfulness meditation, yoga, acupuncture, massage and other brain- or body-based practices — change emotional well-being, and how that in turn relates to whole person health. The R61 phase establishes feasibility over one to two years and, on milestone review, the R33 phase funds the full trial for two to four more. The design requirement is unusual and worth reading closely: the primary outcome must be an innovative MECHANISM of emotional well-being, not symptom reduction, with the Whole Person Health Index as a s

Indicative award
up to $475k per year (per year)Maximum $475,000 in direct costs per year. Combined R61 and R33 project period may not exceed 5 years (R61 phase 1–2 years, R33 phase 2–4 years). NCCIH stated $2,000,000 available in FY2026 for approximately 3 awards.
Timing
Several times a yearSeveral times a year · Feb, Jun, OctPublished deadline: 2026-10-07 — 9 days awayThree cycles a year. Published due dates are February 9, 2026, June 8, 2026, October 7, 2026, then February 8, 2027, June 8, 2027 and October 7, 2027, all by 5:00 PM local time of the applicant organization. The NOFO expires June 8, 2028.
Who can apply
Early-career faculty, Mid-career & senior, Any faculty rank
Eligibility
Higher education institutions, nonprofits with and without 501(c)(3) status, for-profits, small businesses, and federal, state, local and tribal governments may apply. Foreign organizations are NOT eligible. Applications without strong preliminary data are unlikely to be responsive — the NOFO states that preliminary data must be comparable in quality and quantity to that expected for an R01. Community organizations would ordinarily participate as intervention delivery partners under a university-held award.
SSWR clusters
Topics
mind-body interventions · emotional wellbeing · mechanistic trials · whole person health
Apply at
https://grants.nih.gov/grants/guide/pa-files/PAR-25-449.html
This entry
Curated by the working group. Written 2026-08-07. Funder link last confirmed to resolve on 2026-09-25.

Amounts and dates on this page are indicative and are maintained by people rather than scraped. Funders change ceilings, windows and eligibility without notice; confirm all details at the source above before applying.

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