Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 Clinical Trial Optional)
National Institute on Drug Abuse (NIDA), NIH
Phased cooperative-agreement funding to develop and test interventions preventing or treating substance use disorders and overdose, including behavioral interventions and digital therapeutics alongside pharmacological and device approaches.
- Indicative award
- up to $3M per year (per year)Maximum $3 million in direct costs per year; no minimum published.
- Timing
- Several times a yearSeveral times a year · Feb, Jun, OctNo specific published date recorded. This funder publishes a cycle rather than a date, and this database does not invent one.Recurring cycles listed from October 20, 2025 through June 20, 2028, with the NOFO expiring August 22, 2028. The specific next cycle date was not confirmed on the fetched page.
- Who can apply
- Mid-career & senior, Any faculty rank
- Eligibility
- Higher education institutions, nonprofits with or without 501(c)(3) status, for-profits and small businesses, government and tribal agencies, faith- and community-based organizations, and foreign organizations (with restrictions on foreign subawards). Milestone-driven UG3-to-UH3 transition.
- SSWR clusters
- Topics
- intervention development · overdose prevention · behavioral intervention · digital therapeutics · opioid and stimulant use
- Apply at
- https://grants.nih.gov/grants/guide/pa-files/PAR-25-446.html
- This entry
- Curated by the working group. Written 2026-08-07. The funder link has not yet been machine-checked.
Amounts and dates on this page are indicative and are maintained by people rather than scraped. Funders change ceilings, windows and eligibility without notice; confirm all details at the source above before applying.
Also on the Substance Misuse and Addictive Behaviors shelf
- Research Project Grant (R01)National Institutes of Healthup to $250k per year · Several times a year · Feb, Jun, Oct
- Exploratory/Developmental Research Grant (R21)National Institutes of Healthup to $275k · Several times a year · Feb, Jun, Oct
- Ruth L. Kirschstein Predoctoral Individual NRSA (F31)National Institutes of HealthAmount not published · Several times a year · Apr, Aug, Dec
- Mentored Research Scientist Development Award (K01)National Institutes of HealthAmount not published · Several times a year · Feb, Jun, Oct
- Behavioral health services and evaluation grantsSubstance Abuse and Mental Health Services Administration$100k–$5M · Periodic calls
- Minority Fellowship ProgramCouncil on Social Work EducationAmount not published · Annual cycle · Mar, Apr