Broad Pragmatic Studies PCORI Funding Announcement — Cycle 3 2026
Patient-Centered Outcomes Research Institute (PCORI)
PCORI's largest open competition for patient-centered comparative clinical effectiveness research: randomised trials, natural experiments or observational studies. Cycle 3 2026 names special emphasis areas including perinatal mental health and substance use, cancer survivorship, diabetes, and pain management in people with IDD or dementia.
- Indicative award
- up to $12M (total award)$120 million in direct costs committed across the opportunity. Per-project direct-cost caps by category: up to $5 million (Category 1), greater than $5 million up to $12 million (Category 2), up to $12 million for PCORnet studies (Category 3). Project period up to five years. No minimum published.
- Timing
- Several times a yearSeveral times a year · Jan, May, SepPublished deadline: 2026-09-09 — 26 days awayPFA opened Aug. 4, 2026. LOI deadline Sept. 9, 2026, 5 pm ET; invited application deadline Jan. 12, 2027, 5 pm ET. Broad Pragmatic Studies recurs in each of PCORI's roughly three annual research cycles.
- Who can apply
- Any faculty rank, Mid-career & senior, Early-career faculty
- Eligibility
- Organisation-submitted applications that must align with at least one of PCORI's National Priorities for Health and must address PCORI's Foundational Expectations for Partnerships in Research with meaningful patient and partner engagement. Accepted LOI and PCORI invitation required before full application.
- SSWR clusters
- Topics
- comparative clinical effectiveness research · perinatal mental health · cancer survivorship · pain management · pragmatic trials
- Apply at
- https://www.pcori.org/funding-opportunities/announcement/broad-pragmatic-studies-pcori-funding-announcement-cycle-3-2026
- This entry
- Curated by the working group. Written 2026-08-07. The funder link has not yet been machine-checked.
Amounts and dates on this page are indicative and are maintained by people rather than scraped. Funders change ceilings, windows and eligibility without notice; confirm all details at the source above before applying.
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