Addressing Substance Use PCORI Funding Announcement — Cycle 3 2026
Patient-Centered Outcomes Research Institute (PCORI)
Funds patient-centered comparative effectiveness studies of prevention, screening, treatment and recovery approaches for substance use, misuse and substance use disorders at individual, community or systems level. At least one primary outcome must be a substance-use outcome.
- Indicative award
- up to $12M (total award)Up to $60 million available in total; individual applications may request up to $12 million in total direct costs over up to five years. No minimum published.
- Timing
- Several times a yearSeveral times a year · Jan, May, SepPublished deadline: 2026-09-09 — passed. Kept for reference; check the funder's page for the next cycle.PFA opened Aug. 4, 2026. LOI deadline Sept. 9, 2026, 5 pm ET; LOI status Oct. 14, 2026; invited application deadline Jan. 12, 2027, 5 pm ET; merit review March 2027; awards announced August 2027; earliest start December 2027. PCORI runs roughly three research cycles per year.
- Who can apply
- Any faculty rank, Mid-career & senior, Early-career faculty
- Eligibility
- Applications are submitted by organisations and must meaningfully engage patients and other partners under PCORI's Foundational Expectations for Partnerships in Research. An accepted Letter of Intent and a PCORI invitation are required before a full application may be submitted. Studies developing novel interventions, new apps or decision tools, or focused solely on implementation or methods, are nonresponsive.
- SSWR clusters
- Topics
- substance use disorder · overdose prevention · tobacco and nicotine reduction · recovery models · comparative effectiveness
- Apply at
- https://www.pcori.org/funding-opportunities/announcement/addressing-substance-use-pcori-funding-announcement-cycle-3-2026
- This entry
- Curated by the working group. Written 2026-08-07. Funder link last confirmed to resolve on 2026-09-25.
Amounts and dates on this page are indicative and are maintained by people rather than scraped. Funders change ceilings, windows and eligibility without notice; confirm all details at the source above before applying.
Also on the Substance Misuse and Addictive Behaviors shelf
- Minority Fellowship ProgramCouncil on Social Work EducationAmount not published · Annual cycle · Mar, Apr
- Grants to address the overdose crisisFoundation for Opioid Response Efforts$100k–$500k · Periodic calls
- Ruth L. Kirschstein Predoctoral Individual NRSA (F31)National Institutes of HealthAmount not published · Several times a year · Apr, Aug, Dec
- Mentored Research Scientist Development Award (K01)National Institutes of HealthAmount not published · Several times a year · Feb, Jun, Oct
- Research Project Grant (R01)National Institutes of Healthup to $250k per year · Several times a year · Feb, Jun, Oct
- Exploratory/Developmental Research Grant (R21)National Institutes of Healthup to $275k · Several times a year · Feb, Jun, Oct